Saif Aldeen Muhannad Abdullah

Publications

• Brief Report   
  Association of 8-Oxo-2'-Deoxyguanosine, hOGG1 Ser326Cys Gene Polymorphism with Reactive Oxygen Species in Depression Patients
  Author(s): Mona N Al‐Terehi*, Abed J Kadhim, Israa Harjan Mohsen, Marwa Fadhil Alsaffar, Shakir Atiyah, Saif Yaseen Hasan, Doaa A Hamad, Ghadeer Sabah Bustani, Saif Aldeen Muhannad Abdullah and Rehab Subhi Ramadhan
  
  The present work was suggested to study the relation 8-Oxo-2'-deoxyguanosine (8-oxo-dG) with ROS level and hOGG1 gene polymorphism in depression disorder patients, blood samples were collected from study groups to estimate ROS and 8-oxo-dG in addition to DNA extraction to detection hOGG1 Ser326Cys polymorphism using SSCP technique, The results show that there was non-significant in 8-oxo-dG level (P=0.174) and significant differences (P=0.174) in ROS level in study groups, The correlation coefficient between ROS and 8-oxo-dG in shows weak positive correlation in patients group (r-0.188, P 0.426) and nonsignificant weak invers corelation in control group (r-0.074, P 0.719), the target sequence of hOGG gene was amplified to produced 290 pb and genotyping shows three patterns include (3,2 and single haplotype). The pattern of 3 haplotypes didn't observed in pati.. Read More»
  DOI: 10.3371/CSRP.AMAK.261121

  Abstract HTML PDF