Safa K. Hachim
Department of Medical Laboratory Techniques, The Islamic University, Najaf, IraqPublications
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Brief Report
Impact of Apurinic/Apyrimidinic Endonuclease Asp148Glu (rs3136820) Gene Polymorphism and APE1 Level in Depression Disorders Patients
Author(s): Mona N. Al-Terehi, Zahraa F. AL-Khero, Abeer Ameen Baqer, Mohammed Abed Jawad*, Safa K. Hachim, Samah Sajad Kadim, Ali Ahmed Nayyef and Sarah Hussein Ali Alallo
The repair system processes are very important in the maintenance of genome against mutagenic factors, the present study deal with Apurinic/apyrimidinic endonuclease gene polymorphism and its level in depression disorder patients, blood samples were collected from patients and control to serum separation for APE1 detection and DNA extraction for APE1 Asp148Glu (rs3136820) gene polymorphism by CTTP-PCR technique, finding of present research show that the mean age of patients and control were non-significant differences (P 0.156), the BMI was significant differences (P 0.042) between groups. non- significant decrement was appeared in the APE1 level in the patients group (P 0.183), the CTTP-PCR products show two alleles (T and G) and three genotyping in addition to deletion mutation (TT, GT and GG), significant differences was observed in TG allele that low frequent in patients .. Read More»
DOI: 10.3371/.CSRP.AMZA.112621