Mahmood Khudhayer Oglah

Publications

• Research Article   
  Mutual Prodrug of 5-Ethynyluracil and 5-Fluorouracil: Synthesis and Pharmacokinetic Profile
  Author(s): Yasser Fakri Mustafa*, Mahmood Khudhayer Oglah, Moath Kahtan Bashir, Eman Tareq Mohammed and Raghad Riyadh Khalil
  
  The oral administration of the standard cytotoxic agent 5-fluorouracil is extensively limited in the last three decades. This restriction is due to the drug's uneven intestinal absorption due to the changeable activity of dihydropyrimidine dehydrogenase, an enzyme found in the intestinal mucosa. A prodrug containing 5-fluorouracil and 5-ethynyluracil was developed in this study to allow mutual release of these two active medicines via a lactonization-facilitated release mechanism. Using coumarin as a precursor, the synthesis of the target prodrug was carried out in seven stages. The chemical backbones of the synthesized intermediate molecules and the target prodrug were verified using spectra acquired from several spectrophotometers, including FTIR, 1H-NMR, and 13C-NMR. In the HCl- (pH 1.2) and phosphate- (pH 6.8) buffers, the target prodrug's chemical stabi.. Read More»
  

  Abstract PDF