Alaa Ibraheem Lazim
Department of Pharmacy, Al-Manara University, Maysan, IraqPublications
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Brief Report
The Mitochondrial DNA D-Loop Variations in Depressed Patients
Author(s): Alaa Ibraheem Lazim, Hajer Ali Enad, Ahmed Khalid Aldhalmi, Albab Fawwaz Alfarras, Hawraa Fadhel Abbas AL-Baghdady, Noora M Hameed*, Sundus Mohammad Ali Al-Bazi and Ali Jalil Obaid
Depression is one of an important health problems in the last years, the predisposition to the depression still under investigations, the present study deal with the mtDNA variation loci in depression patients compare with control, PCR-sequencing was used to determine mutations, results show that there were among 173 nucleotides of the D-loop (16034-16207) there were 19 sites differentiated in non-significant differences, about 8 types of substitution mutations were observed included (A>C, A>G, T>C, G>A, C>T, C>A, C>G, G>A), insertion and deletion mutations also founded, non-significant differences were appeared in the types and number of mutations in this segment of mtDNA. The present output concluded that there wasn’t association between D-loop variations and depression disease... Read More»
DOI: 10.3371/CSRP.AMHE.091221