Abstract

The Systemic Lupus Erythematous (SLE) disease is an autoimmune disease incidence by different genetic and environment factors, the present research study two DNA repair genes polymorphisms in SLE disease included RAD-18 Arg302Gln (rs373572) and OGG1 Ser326Cys (rs1052133) genes, the polymorphisms were detection using allele specific PCR and PCR-SSCP, patients were diagnostic by specialist physician then DNA was isolated from whole blood, the results show that The RAD-18 gene variation show non-significant differences between patients and control, tow genotyping (AA and AG) were observed and GG didn’t observed, the distribution of AA and AG were 95.29% of patients have AA while 92.85% in control GG appeared in 4.76% of patients and 7.14% in control (OR 0.6667, P value 0.6936). The OGG1 Ser326Cys (rs1052133) genes polymorphisms shows there haplotypes A, B, and C represented by four pattern ABC, AC, A and C. AC (47.5%), C (30%) and A (12.5%) were more frequent in patients than control in significant level for AC (OR 8.1429, P 0.0006) and non- significant level for C (OR 5.029, P 0.0574) and A (OR 0.1196, P 0.167). the present finding concluded that SLE association with OGG1, and don’t related with RAD-18.

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