Abstract
The Dopamine Level and Dopaminergic Receptor Gene: DOR1 VNTR in Smokers
Author(s): Huda Khalil Yaseen, Mizher Khlif Hsony, Omar Sinan Sadiq Al‐Zaidi, Ali Abdulhussain Fadhil, Zainab Sami Abbas, Usama S. Altimari* and Mona N. Al‐TerehiThe smoking is a common habit in the world which contributed in several diseases, the dopamine and its receptors were found to be related with addictive, in Iraq high percentage of population was smokers and others suffer from passive smokers, thus current study aims to detect, the Dopamine Level and Dopaminergic receptor Gene In young Smokers. The dopamine level and Dopaminergic Genes VNTR were detected using VNTR-PCR and ELIZA technique, the results show that non-significant differences in age and BMI (p=0.553, and p=0.638) and non-significant differences in dopamine levels between groups (p=0.823), three VNTR were observed 11(520 bp), 10 (483 bp) and 7(361 bp). The VNTR11 is more frequent in the smoker group (83.33%) in non-significant variation (p=0.966), also VNTR 10 are more frequent in the smoker group (16.66%) in non-significant variation (p=0.894), and VNTR 7 didn’t observe in the smoker group. Significant differences observed in non-smoker dopamine level according to VNTR frequency (p=0.025) while non-significant observed in the smoker group (p=0.324). The study concluded that the dopamine level didn’t effect by smoking and VNTR of DAT1 gene didn’t associate with the smoking habit also.