Abstract
Comorbidity of Neurocysticercosis, HIV, Cerebellar Atrophy and SARS-CoV-2: Case Report and Systematic Review
Author(s): Humberto Foyaca Sibat*Background: On November 24, 2021, the omicron (B.1.1.529) variant of SARS-CoV-2 was first reported to WHO from this country. Whether the association of Omicron (Om) variant of concern (VoC), neurocysticercosis, and Cerebellar Atrophy (CA) in people living with HIV/AIDS (PLWHA) is actual or fictitious, require to be investigated and what is the most probable pathogenesis of SARS-CoV-2 mutation deserved to be analysed.
Method: We performed a comprehensive search of publications on PLWHA/NCC/CA/COVID-19-Om written in English, Spanish, and Portuguese. Results: Forty-five cases presented COVID-19 and cerebellar manifestations, mainly cerebellar ataxia with a mean age of 54.3 ± 12.3 years, were identified. No patients presenting an associated HIV/AIDS/NCC/Om VoC were found.
Case presentation: A 32-year-old-male HIV-positive patient on treatment with a past medical history of NCC and CA infected by SARS-CoV-2 Om VoC is reported. Comments: We considered theca in our patient is secondary to prolonged consumption of antiepileptic medication. The current fourth wave of COVID-19 is heralded by the Om variant, which is spreading faster worldwide, suggesting it has a growth advantage. In our opinion, those fully vaccinated infected by Om, after recovery from their "Flu", will remain super immunized, which will probably be the beginning of the end of the current pandemic.
Conclusion: The role of SARS-CoV-2 speedy the mechanism of T cell exhaustion and its capacity to decrease the production of INFγ, IL-2, and TNFα must not be ignored in future medical research. It is the first report on PLWHANCA, Om reported in the medical literature up to date from our knowledge.
Abbreviations: CAV: Coxsackievirus, Rubeola, Varicella; TI/T: Traumatic Insults and Toxins; A/I: Anoxic Brain Injury; M/X-L: Mitochondrial and X-Linked Diseases; CVH: Congenital Vermian Hypoplasia; DWM: Dandy-Walker Malformation; ET: Elevation of Torcula; JSRD: Joubert-Syndrome-related Disorders; IH/AV: Inherited Hypoplasia or Aplasia of The Vermis; MTB: Molar Tooth Brainstem; B/US4V: Batwing or Umbrella-Shaped Fourth Ventricle; PCH: Pontocerebellar Hypoplasia; ARD: Autosomal Recessive Disorder Present at or Before Birth; M: Microcephaly; ISCA: Inherited Spinocerebellar Ataxia, NI-TSE S: Non-Inherited Transmissible Spongiform Encephalopathies; PND: Paraneoplastic Disorders; ND: Nutritional Deficiency